Medicines Co. Licenses Rights to Cholesterol Drug



The drug, known as ALN-PCS, inhibits a protein in the body known as PCSK9. Such drugs might one day be used to treat millions of people who do not achieve sufficient cholesterol-lowering from commonly used statins, such as Lipitor.


The Medicines Company will pay $25 million initially and as much as $180 million later if certain development and sales goals are met, under the deal expected to be formally announced Monday. It will also pay Alnylam, which is based in Cambridge, Mass., double-digit royalties on global sales.


That is small payment for a drug with presumably a huge potential market, probably reflecting that Alnylam is still in the first of three phases of clinical trials, well behind some far bigger competitors.


The team of Sanofi and Regeneron Pharmaceuticals is already entering the third and final stage of trials with their PCSK9 inhibitor, as is Amgen. Pfizer and Roche are in midstage trials.


ALN-PCS is different from the other drugs. It uses a gene-silencing mechanism called RNA interference, aimed at shutting off production of the PCSK9 protein. The other drugs are proteins called monoclonal antibodies that inhibit the action of PCSK9 after it has been formed.


Alnylam and the Medicines Company hope that turning off the faucet, as it were, will be more efficient than mopping the floor, allowing their drug to be given less frequently and in smaller amounts.


But that has yet to be proved. No drug using RNA interference has reached the market.


The Medicines Company, based in Parsippany, N.J., generates almost all of its revenue from one product — Angiomax, an anticlotting drug used when patients receive stents to open clogged arteries.


Dr. Clive A. Meanwell, chief executive of the company, said that PCSK9 inhibitors are likely to be used at first mainly by patients with severe lipid problems under the care of interventional cardiologists, the same doctors who use Angiomax. “It really is quite adjacent to what we do,” he said.


The Medicines Company licensed Angiomax from Biogen Idec, where the drug was invented and initially developed under a team led by Dr. John M. Maraganore, who is now the chief executive of Alnylam.


“It’s a bit like getting the band back together,” Dr. Maraganore said.


Read More..

Medicines Co. Licenses Rights to Cholesterol Drug



The drug, known as ALN-PCS, inhibits a protein in the body known as PCSK9. Such drugs might one day be used to treat millions of people who do not achieve sufficient cholesterol-lowering from commonly used statins, such as Lipitor.


The Medicines Company will pay $25 million initially and as much as $180 million later if certain development and sales goals are met, under the deal expected to be formally announced Monday. It will also pay Alnylam, which is based in Cambridge, Mass., double-digit royalties on global sales.


That is small payment for a drug with presumably a huge potential market, probably reflecting that Alnylam is still in the first of three phases of clinical trials, well behind some far bigger competitors.


The team of Sanofi and Regeneron Pharmaceuticals is already entering the third and final stage of trials with their PCSK9 inhibitor, as is Amgen. Pfizer and Roche are in midstage trials.


ALN-PCS is different from the other drugs. It uses a gene-silencing mechanism called RNA interference, aimed at shutting off production of the PCSK9 protein. The other drugs are proteins called monoclonal antibodies that inhibit the action of PCSK9 after it has been formed.


Alnylam and the Medicines Company hope that turning off the faucet, as it were, will be more efficient than mopping the floor, allowing their drug to be given less frequently and in smaller amounts.


But that has yet to be proved. No drug using RNA interference has reached the market.


The Medicines Company, based in Parsippany, N.J., generates almost all of its revenue from one product — Angiomax, an anticlotting drug used when patients receive stents to open clogged arteries.


Dr. Clive A. Meanwell, chief executive of the company, said that PCSK9 inhibitors are likely to be used at first mainly by patients with severe lipid problems under the care of interventional cardiologists, the same doctors who use Angiomax. “It really is quite adjacent to what we do,” he said.


The Medicines Company licensed Angiomax from Biogen Idec, where the drug was invented and initially developed under a team led by Dr. John M. Maraganore, who is now the chief executive of Alnylam.


“It’s a bit like getting the band back together,” Dr. Maraganore said.


Read More..

IHT Rendezvous: Doctors to Prescribe Self-Help Books, Poetry for Mental Health Ills

LONDON — Doctors in England will soon be prescribing books as well as pills to patients suffering from anxiety and depression.

In a government-endorsed initiative supported by medical associations and librarians, physicians will be sending patients to their local libraries for a range of approved self-help titles targeted at those suffering from mild to moderate mental health problems.

Patients are also being encouraged to turn to what The Bookseller magazine described as “uplifting novels and poetry.”

Extolling the potentially curative powers of literature, the Reading Agency charity quoted research that showed reading reduced stress levels by 67 percent.

The charity, which is a partner in the new Books on Prescription program announced this week, quoted the New England Journal of Medicine as saying reading also cut the risk of dementia by more than a third.

The list of 30 approved self-help titles available on prescription from May includes page-turners like “The Feeling Good Handbook,” “How to Stop Worrying” and “Overcoming Anger and Irritability.”

“There’s growing evidence that shows that self-help reading can help people with certain mental health issues get better,” Miranda McKearney, the Reading Agency’s director said.

The sick often rely on the Internet to search for advice on symptoms and cures that can turn out to be unreliable. Doctors will now be able to write a prescription that gives patients immediate membership to their local library and access to recommended titles.

It is the first so-called bibliotherapy initiative to have received such high-level official backing from health authorities and librarians.

Campaigners for public libraries have applauded the program but worry that not enough is being done to protect the libraries themselves. Last year, 200 libraries were closed and another 300 are reportedly facing closure or being handed over to volunteers this year.

The Reading Agency meanwhile has come up with a core list of Mood-boosting Books designed to promote feeling good.

It includes proven classics such as “The Secret Garden,” by Frances Hodgson Burnett, but also upbeat titles from the likes of Bill Bryson, the best-selling U.S. humorist.

Development of the book prescription idea was paid for by the Arts Council England, which distributes public money to arts projects.

The Reading Agency has applied for funding from the government, which it says spends £14 billion, or $22 billion, a year treating mental health.

So, should sufferers of depression or panic attacks be advised to curl up with a good book? Or is this just a new health fad to find an alternative to costly medication and therapy.

The Reading Project is soliciting suggestions for stress-relieving books at the Twitter hashtag #moodboosting.

If you think there might be something in it, send us your own suggestions for therapeutic reading. And, while you’re at it, let us know any titles that are best avoided when we’re feeling low.

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Slipstream: Consumer Data Protection Laws, an Ocean Apart





OVER the years, the United States and Europe have taken different approaches toward protecting people’s personal information. Now the two sides are struggling to bridge that divide.




On this side of the Atlantic, Congress has enacted a patchwork quilt of privacy laws that separately limit the use of Americans’ medical records, credit reports, video rental records and so on. On the other side, the European Union has instituted more of a blanket regulatory system; it has a common directive that gives its citizens certain fundamental rights — like the right to obtain copies of records held about them by companies and institutions — that Americans now lack.


Even so, United States officials maintain that the divergent approaches are equal. “The sum of the parts of U.S. privacy protection is equal to or greater than the single whole of Europe,” says Cameron F. Kerry, general counsel of the Commerce Department. He is overseeing an agency effort to help develop voluntary, enforceable codes of conduct for industry groups, like app developers, whose collection and use of consumer data are now unregulated.


Europe begs to differ.


“Yes, we share the basic idea of privacy,” says Peter Hustinx, Europe’s data protection supervisor. “But there is a huge deficit on the U.S. side.”


Alas, the data-control divide appears to be widening.


A year ago, the European Commission proposed comprehensive reforms to strengthen online privacy rights — changes that could have big repercussions for American technology companies and marketers that operate in the European Union. American officials, trade groups and tech executives have responded by taking frequent treks to Brussels and other cities, where they have urged regulators and legislators to reconsider the one-regulation-fits-all-data approach. What’s at stake, American industry representatives say, is nothing less than a free and commerce-friendly Internet.


“The ecosystem of the Internet is very delicate,” says Kevin Richards, senior vice president of federal government affairs at TechAmerica, a trade group that represents companies like Google and Microsoft. “It’s not wise to have an overly broad, prescriptive, one-size-fits-all approach that would hinder or undermine the ability of companies to innovate in a global economy.”


European Union members already have data protection laws in place, based on a directive from 1995 that laid out principles for the collection of personal information. The proposed new rules would strengthen some existing provisions. They would standardize data protections across the 27 member states. They would also provide some new rights, such as “data portability” — the right of consumers to easily transfer their text files, photographs and videos from one social network, or e-mail or cloud storage service, to another. And they would subject companies that violate the rules to penalties of up to 2 percent of their annual global revenue.


Asked for comment, Viviane Reding, the vice president of the European Commission and the architect of the proposed regulation, said in a statement: “The main problem is that our rules predate the digital age and it became increasingly clear in recent years that they needed an update.” She continued: “That is why I have proposed a root-and-branch reform of the E.U.’s data protection rules — currently under discussion in the European Parliament and the Council of the E.U. — that will both protect citizens’ rights and facilitate business in the digital age.”


BUT some provisions seem too rigid to United States officials and trade groups. They argue that the American approach — sector-specific privacy laws, in addition to industry self-regulation and enforcement by the Federal Trade Commission — is more nimble.


“We hope that Europe will move in the direction of those multistakeholder standards, and not standards which are not flexible and don’t move at Internet speed,” says Mr. Kerry, who has taken at least four trips to European cities in the last year to discuss these issues.


From the perspective of some European legislators, however, United States representatives seem more interested in protecting commerce than consumers. The full-court American effort may have backfired, they say, pushing some European officials toward even broader measures. Last month, Jan Philipp Albrecht, a representative of the European Parliament who reviewed the draft regulation, proposed additional rights for citizens — like the right not to be subject to consumer profiling.


“My impression is that the U.S. Chamber of Commerce and the Commerce Department are mostly just following the interests of Silicon Valley,” he says. “This leads to heavy pressure on the European regulator, I can say.”


But Mr. Kerry says the United States must make its views known if the systems are to work in concert.


“I know that some people have raised eyebrows at our involvement; I make no apologies,” Mr. Kerry says. “We in the United States and countries and businesses around the world are stakeholders in this process. This has an important impact on the global economy.”


The solution to this trans-Atlantic clash may simply be American ingenuity.


Last year, President Barack Obama proposed a “Consumer Privacy Bill of Rights” that would give Americans many of the same baseline protections that the draft European rule proposes to reinforce. These include the right of access to records that companies hold about them, the right to correct those records and the right to have limits on the personal data that companies collect and keep. Administration officials said they would work with Congress on legislation based on those rights and to extend oversight to industries not currently covered by federal privacy laws.


A coalition of more than a dozen American advocacy groups said it would send a letter on Monday to senior Obama administration officials, seeking a meeting to ensure that American policy makers’ efforts in Europe “are not averse to the views expressed by the president.” The coalition includes the Electronic Privacy Information Center and the Center for Digital Democracy.


“Does the Obama administration really want to be on the opposite side of the European effort to upgrade and modernize its privacy law which is at its core about the protection of a fundamental freedom?” asks Marc Rotenberg, executive director of the Electronic Privacy Information Center.


European officials hold out hope that Congress will enact baseline consumer privacy protections for Americans.


“This development — which is much welcomed in Europe — shows that we have much in common,” Ms. Reding of the European Commission said in her statement, speaking of the privacy bill of rights. “Convergence is springing up and synergies are possible.”


E-mail: slipstream@nytimes.com.



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Iceland, Prosecutor of Bankers, Sees Meager Returns


Ilvy Njiokiktjien for The New York Times


"Greed is not a crime. But the question is: where does greed lead?" said Olafur Hauksson, a special prosecutor in Reykjavik.







REYKJAVIK, Iceland — As chief of police in a tiny fishing town for 11 years, Olafur Hauksson developed what he thought was a basic understanding of the criminal mind. The typical lawbreaker, he said, recalling his many encounters with small-time criminals, “clearly knows that he crossed the line” and generally sees “the difference between right and wrong.”




Today, the burly, 48-year-old former policeman is struggling with a very different sort of suspect. Reassigned to Reykjavik, the Icelandic capital, to lead what has become one of the world’s most sweeping investigation into the bankers whose actions contributed to the global financial crisis in 2008, Mr. Hauksson now faces suspects who “are not aware of when they crossed the line” and “defend their actions every step of the way.”


With the global economy still struggling to recover from the financial maelstrom five years ago, governments around the world have been criticized for largely failing to punish the bankers who were responsible for the calamity. But even here in Iceland, a country of just 320,000 that has gone after financiers with far more vigor than the United States and other countries hit by the crisis, obtaining criminal convictions has proved devilishly difficult.


Public hostility toward bankers is so strong in Iceland that “it is easier to say you are dealing drugs than to say you’re a banker,” said Thorvaldur Sigurjonsson, the former head of trading for Kaupthing, a once high-flying bank that crumbled. He has been called in for questioning by Mr. Hauksson’s office but has not been charged with any wrongdoing.


Yet, in the four years since the Icelandic Parliament passed a law ordering the appointment of an unnamed special prosecutor to investigate those blamed for the country’s spectacular meltdown in 2008, only a handful of bankers have been convicted.


Ministers in a left-leaning coalition government elected after the crash agree that the wheels of justice have ground slowly, but they call for patience, explaining that the process must follow the law, not vengeful passions.


“We are not going after people just to satisfy public anger,” said Steingrimur J. Sigfusson, Iceland’s minister of industry, a former finance minister and leader of the Left-Green Movement that is part of the governing coalition.


Hordur Torfa, a popular singer-songwriter who helped organize protests that forced the previous conservative government to resign, acknowledged that “people are getting impatient” but said they needed to accept that “this is not the French Revolution. I don’t believe in taking bankers out and hanging them or shooting them.”


Others are less patient. “The whole process is far too slow,” said Thorarinn Einarsson, a left-wing activist. “It only shows that ‘banksters’ can get away with doing whatever they want.”


Mr. Hauksson, the special prosecutor, said he was frustrated by the slow pace but thought it vital that his office scrupulously follow legal procedure. “Revenge is not something we want as our main driver in this process. Our work must be proper today and be seen as proper in the future,” he said.


Part of the difficulty in prosecuting bankers, he said, is that the law is often unclear on what constitutes a criminal offense in high finance. “Greed is not a crime,” he noted. “But the question is: where does greed lead?”


Mr. Hauksson said it was often easy to show that bankers violated their own internal rules for lending and other activities, but “as in all cases involving theft or fraud, the most difficult thing is proving intent.”


And there are the bankers themselves. Those who have been brought in for questioning often bristle at being asked to account for their actions. “They are not used to being questioned. These people are not used to finding themselves in this situation,” Mr. Hauksson said. They also hire expensive lawyers.


The special prosecutor’s office initially had only five staff members but now has more than 100 investigators, lawyers and financial experts, and it has relocated to a big new office. It has opened about 100 cases, with more than 120 people now under investigation for possible crimes relating to an Icelandic financial sector that grew so big it dwarfed the rest of the economy.


To help ease Mr. Hauksson’s task, legislators amended the law to allow investigators easy access to confidential bank information, something that previously required a court order.


Parliament also voted to put the country’s prime minister at the time of the banking debacle on trial for negligence before a special tribunal. (A proposal to try his cabinet failed.) Mr. Hauksson was not involved in the case against the former leader, Geir H. Haarde, who last year was found guilty of failing to keep ministers properly informed about the 2008 crisis but was acquitted on more serious charges that could have resulted in a prison sentence.


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Concerns About A.D.H.D. Practices and Amphetamine Addiction


Before his addiction, Richard Fee was a popular college class president and aspiring medical student. "You keep giving Adderall to my son, you're going to kill him," said Rick Fee, Richard's father, to one of his son's doctors.







VIRGINIA BEACH — Every morning on her way to work, Kathy Fee holds her breath as she drives past the squat brick building that houses Dominion Psychiatric Associates.










Andrea Mohin/The New York Times

MENTAL HEALTH CLINIC Dominion Psychiatric Associates in Virginia Beach, where Richard Fee was treated by Dr. Waldo M. Ellison. After observing Richard and hearing his complaints about concentration, Dr. Ellison diagnosed attention deficit hyperactivity disorder and prescribed the stimulant Adderall.






It was there that her son, Richard, visited a doctor and received prescriptions for Adderall, an amphetamine-based medication for attention deficit hyperactivity disorder. It was in the parking lot that she insisted to Richard that he did not have A.D.H.D., not as a child and not now as a 24-year-old college graduate, and that he was getting dangerously addicted to the medication. It was inside the building that her husband, Rick, implored Richard’s doctor to stop prescribing him Adderall, warning, “You’re going to kill him.”


It was where, after becoming violently delusional and spending a week in a psychiatric hospital in 2011, Richard met with his doctor and received prescriptions for 90 more days of Adderall. He hanged himself in his bedroom closet two weeks after they expired.


The story of Richard Fee, an athletic, personable college class president and aspiring medical student, highlights widespread failings in the system through which five million Americans take medication for A.D.H.D., doctors and other experts said.


Medications like Adderall can markedly improve the lives of children and others with the disorder. But the tunnel-like focus the medicines provide has led growing numbers of teenagers and young adults to fake symptoms to obtain steady prescriptions for highly addictive medications that carry serious psychological dangers. These efforts are facilitated by a segment of doctors who skip established diagnostic procedures, renew prescriptions reflexively and spend too little time with patients to accurately monitor side effects.


Richard Fee’s experience included it all. Conversations with friends and family members and a review of detailed medical records depict an intelligent and articulate young man lying to doctor after doctor, physicians issuing hasty diagnoses, and psychiatrists continuing to prescribe medication — even increasing dosages — despite evidence of his growing addiction and psychiatric breakdown.


Very few people who misuse stimulants devolve into psychotic or suicidal addicts. But even one of Richard’s own physicians, Dr. Charles Parker, characterized his case as a virtual textbook for ways that A.D.H.D. practices can fail patients, particularly young adults. “We have a significant travesty being done in this country with how the diagnosis is being made and the meds are being administered,” said Dr. Parker, a psychiatrist in Virginia Beach. “I think it’s an abnegation of trust. The public needs to say this is totally unacceptable and walk out.”


Young adults are by far the fastest-growing segment of people taking A.D.H.D medications. Nearly 14 million monthly prescriptions for the condition were written for Americans ages 20 to 39 in 2011, two and a half times the 5.6 million just four years before, according to the data company I.M.S. Health. While this rise is generally attributed to the maturing of adolescents who have A.D.H.D. into young adults — combined with a greater recognition of adult A.D.H.D. in general — many experts caution that savvy college graduates, freed of parental oversight, can legally and easily obtain stimulant prescriptions from obliging doctors.


“Any step along the way, someone could have helped him — they were just handing out drugs,” said Richard’s father. Emphasizing that he had no intention of bringing legal action against any of the doctors involved, Mr. Fee said: “People have to know that kids are out there getting these drugs and getting addicted to them. And doctors are helping them do it.”


“...when he was in elementary school he fidgeted, daydreamed and got A’s. he has been an A-B student until mid college when he became scattered and he wandered while reading He never had to study. Presently without medication, his mind thinks most of the time, he procrastinated, he multitasks not finishing in a timely manner.”


Dr. Waldo M. Ellison


Richard Fee initial evaluation


Feb. 5, 2010


Richard began acting strangely soon after moving back home in late 2009, his parents said. He stayed up for days at a time, went from gregarious to grumpy and back, and scrawled compulsively in notebooks. His father, while trying to add Richard to his health insurance policy, learned that he was taking Vyvanse for A.D.H.D.


Richard explained to him that he had been having trouble concentrating while studying for medical school entrance exams the previous year and that he had seen a doctor and received a diagnosis. His father reacted with surprise. Richard had never shown any A.D.H.D. symptoms his entire life, from nursery school through high school, when he was awarded a full academic scholarship to Greensboro College in North Carolina. Mr. Fee also expressed concerns about the safety of his son’s taking daily amphetamines for a condition he might not have.


“The doctor wouldn’t give me anything that’s bad for me,” Mr. Fee recalled his son saying that day. “I’m not buying it on the street corner.”


Read More..

Concerns About A.D.H.D. Practices and Amphetamine Addiction


Before his addiction, Richard Fee was a popular college class president and aspiring medical student. "You keep giving Adderall to my son, you're going to kill him," said Rick Fee, Richard's father, to one of his son's doctors.







VIRGINIA BEACH — Every morning on her way to work, Kathy Fee holds her breath as she drives past the squat brick building that houses Dominion Psychiatric Associates.










Andrea Mohin/The New York Times

MENTAL HEALTH CLINIC Dominion Psychiatric Associates in Virginia Beach, where Richard Fee was treated by Dr. Waldo M. Ellison. After observing Richard and hearing his complaints about concentration, Dr. Ellison diagnosed attention deficit hyperactivity disorder and prescribed the stimulant Adderall.






It was there that her son, Richard, visited a doctor and received prescriptions for Adderall, an amphetamine-based medication for attention deficit hyperactivity disorder. It was in the parking lot that she insisted to Richard that he did not have A.D.H.D., not as a child and not now as a 24-year-old college graduate, and that he was getting dangerously addicted to the medication. It was inside the building that her husband, Rick, implored Richard’s doctor to stop prescribing him Adderall, warning, “You’re going to kill him.”


It was where, after becoming violently delusional and spending a week in a psychiatric hospital in 2011, Richard met with his doctor and received prescriptions for 90 more days of Adderall. He hanged himself in his bedroom closet two weeks after they expired.


The story of Richard Fee, an athletic, personable college class president and aspiring medical student, highlights widespread failings in the system through which five million Americans take medication for A.D.H.D., doctors and other experts said.


Medications like Adderall can markedly improve the lives of children and others with the disorder. But the tunnel-like focus the medicines provide has led growing numbers of teenagers and young adults to fake symptoms to obtain steady prescriptions for highly addictive medications that carry serious psychological dangers. These efforts are facilitated by a segment of doctors who skip established diagnostic procedures, renew prescriptions reflexively and spend too little time with patients to accurately monitor side effects.


Richard Fee’s experience included it all. Conversations with friends and family members and a review of detailed medical records depict an intelligent and articulate young man lying to doctor after doctor, physicians issuing hasty diagnoses, and psychiatrists continuing to prescribe medication — even increasing dosages — despite evidence of his growing addiction and psychiatric breakdown.


Very few people who misuse stimulants devolve into psychotic or suicidal addicts. But even one of Richard’s own physicians, Dr. Charles Parker, characterized his case as a virtual textbook for ways that A.D.H.D. practices can fail patients, particularly young adults. “We have a significant travesty being done in this country with how the diagnosis is being made and the meds are being administered,” said Dr. Parker, a psychiatrist in Virginia Beach. “I think it’s an abnegation of trust. The public needs to say this is totally unacceptable and walk out.”


Young adults are by far the fastest-growing segment of people taking A.D.H.D medications. Nearly 14 million monthly prescriptions for the condition were written for Americans ages 20 to 39 in 2011, two and a half times the 5.6 million just four years before, according to the data company I.M.S. Health. While this rise is generally attributed to the maturing of adolescents who have A.D.H.D. into young adults — combined with a greater recognition of adult A.D.H.D. in general — many experts caution that savvy college graduates, freed of parental oversight, can legally and easily obtain stimulant prescriptions from obliging doctors.


“Any step along the way, someone could have helped him — they were just handing out drugs,” said Richard’s father. Emphasizing that he had no intention of bringing legal action against any of the doctors involved, Mr. Fee said: “People have to know that kids are out there getting these drugs and getting addicted to them. And doctors are helping them do it.”


“...when he was in elementary school he fidgeted, daydreamed and got A’s. he has been an A-B student until mid college when he became scattered and he wandered while reading He never had to study. Presently without medication, his mind thinks most of the time, he procrastinated, he multitasks not finishing in a timely manner.”


Dr. Waldo M. Ellison


Richard Fee initial evaluation


Feb. 5, 2010


Richard began acting strangely soon after moving back home in late 2009, his parents said. He stayed up for days at a time, went from gregarious to grumpy and back, and scrawled compulsively in notebooks. His father, while trying to add Richard to his health insurance policy, learned that he was taking Vyvanse for A.D.H.D.


Richard explained to him that he had been having trouble concentrating while studying for medical school entrance exams the previous year and that he had seen a doctor and received a diagnosis. His father reacted with surprise. Richard had never shown any A.D.H.D. symptoms his entire life, from nursery school through high school, when he was awarded a full academic scholarship to Greensboro College in North Carolina. Mr. Fee also expressed concerns about the safety of his son’s taking daily amphetamines for a condition he might not have.


“The doctor wouldn’t give me anything that’s bad for me,” Mr. Fee recalled his son saying that day. “I’m not buying it on the street corner.”


Read More..

Marxist Group Claims Attack on Embassy in Turkey





ISTANBUL — In a statement that called the United States “the murderer of the peoples of the world,” a Marxist group, with a history of political violence in Turkey, claimed responsibility for a suicide bombing at the American Embassy in Ankara.




The statement, which also denounced American foreign policy, was reportedly released by the Revolutionary People’s Liberation Party, and a translation was distributed by the Site Intelligence Group, which monitors the communications of extremist groups. The message, which was released on a Web site that has previously carried statements from the group, condemned Turkey’s policy of supporting Syria’s rebels against the government of Bashar al-Assad.


The statement included details that were similar to those released so far by the Turkish authorities, although the group’s message had a different first name for the bomber than the one given by Turkish officials and reported in the local news media.


The Turkish authorities said Saturday that the man who detonated himself at the American Embassy in Ankara on Friday, killing himself and one other, was a convicted terrorist who had twice attacked government facilities in Istanbul but was released from prison under an amnesty program.


Officials in Ankara said Saturday they were awaiting the results of a DNA test before releasing the bomber’s name, but officials in the Black Sea coastal town of Ordu identified him as Ecevit Sanli, 40, and said he was a registered citizen of their town. Authorities in Ordu said the bomber was identified by relatives through photographs.


The statement by the militant group included two photographs of the bomber (in one, he is holding an assault rifle, and a banner bearing the hammer-and-sickle communist symbol is behind him) that appeared to be the same person seen in photographs published by the news media. The group identified the bomber with the first name “Alisan.”


The attack, coming in the wake of the assault on an American diplomatic facility in Benghazi, Libya, by Islamic extremists, raised fears that it was the work of jihadists. That the bomber appears to have ties to a relatively minor Marxist group, which was responsible for political violence in the 1970s, is likely to challenge assumptions about the nature of international terrorism and the risks to American interests abroad. American officials, however, have not confirmed the identity of the attacker, nor a motive, and the United States plans to conduct an investigation.


The statement from officials in Ordu said on Saturday that Mr. Sanli spent four years in prison after being arrested in 1997 for attacking a military hostel and police station in Istanbul. He was then released in 2001 under an amnesty program for inmates with medical conditions, the statement said.


The authorities said Mr. Sanli lobbed a hand grenade during Friday’s attack just before detonating himself, suggesting there were actually two explosions.


As the investigation continues, the authorities are trying to determine whether Mr. Sanli had any collaborators. The Turkish newspaper Hurriyet reported that Mr. Sanli had fled to Germany after being released from prison, and had returned to Turkey only a few days before the attack.


The group has struck American and western targets in Turkey before, including during the gulf war in the early 1990s, and in its statement Saturday, the group condemned the recent deployment by NATO of Patriot missile batteries in southern Turkey.


In a report published several days before the bombing, Soner Cagaptay, director of the Turkish research program at the Washington Institute for Near East Policy, warned that Turkey’s support of Syrian rebels in their fight against the government of Mr. al-Assad, as well as the deployment by NATO of Patriot missile batteries, was rallying Turkey’s extreme left.


“The country’s political landscape still bears vestiges of violent leftist movements from the 1970s, as well as deeply anti-American ultranationalism,” he wrote. Mr. Cagaptay noted that some militant left-wing groups organized protests against the Patriot missile deployment in the southern port city of Iskenderun, where protesters have fired smoke grenades at NATO troops and burned American flags.


Sebnem Arsu contributed reporting.



This article has been revised to reflect the following correction:

Correction: February 2, 2013

An earlier version of this article misstated, based on information supplied by the authorities, the year when Ecevit Sanli was released from prison. It was 2001, not 2002.



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Bits Blog: The Origins of ‘Big Data’: An Etymological Detective Story

Words and phrases are fundamental building blocks of language and culture, much as genes and cells are to the biology of life. And words are how we express ideas, so tracing their origin, development and spread is not merely an academic pursuit but a window into a society’s intellectual evolution.

Digital technology is changing both how words and ideas are created and proliferate, and how they are studied. Just last month, for example, the Library of Congress said its archive of public Twitter messages has reached 170 billion tweets and rising, by about 500 million tweets a day.

The Library of Congress archive, resulting from a deal struck with Twitter in 2010, is not yet open to researchers. But the plan is that it soon will be. In a white paper, the Library said that social media promises to be a rich resource that provides “a fuller picture of today’s cultural norms, dialogue, trends and events to inform scholarship, the legislative process, new works of authorship, education and other purposes.”

The new digital forms of communication — Web sites, blog posts, tweets — are often very different from the traditional sources for the study of words, like books, news articles and academic journals.

“It’s almost like oral language instead of edited text,” said Fred R. Shapiro, editor of the “Yale Book of Quotations” and an associate librarian at the Yale Law School. “It’s the way of the future.”

The unruly digital data of the Web is a big ingredient in what is now being called “Big Data.” And as it turns out, the term Big Data seems to be most accurately traced not to references in news or journal archives, but to digital artifacts now posted on technical Web sites, appropriately enough.

To our modest tale of word sleuthing: Last August, I wrote a Sunday column about 2012 being the breakout year for Big Data as an idea, in the marketplace, and as a term.

At the time, I did some reporting on the roots of the term, and I asked Mr. Shapiro of Yale to dig into it. He scoured data bases and came up with several references, including in press releases for product announcements and one intriguing use of the term by a now-famous author (more on that later).

But Mr. Shapiro couldn’t find anything as crisp and definitive as he had done for me years earlier when I asked him to try to find the first reference to the word “software” as a computing term. It was in 1958, in an article in “The American Mathematical Monthly,” written by John Tukey, a Princeton mathematician.

So, without a conclusive answer, I didn’t write about the origins of the term Big Data in that Sunday column. But afterward, I heard from people who had ideas on the subject.

Francis X. Diebold, an economist at the University of Pennsylvania, got in touch and even wrote a paper, with the mildly tongue-in-cheek title, “I Coined the Term ‘Big Data’ ” I had not thought of economics as the breeding ground for the term, but it is not unreasonable. Some of the statistical and algorithmic methods now in the Big Data tool kit trace their heritage to economic modeling and Wall Street.

Mr. Diebold staked a claim based on his paper, “Big Data Dynamic Factor Models for Macroeconomic Measurement and Forecasting,” presented in 2000 and published in 2003. The economic-modeling paper was first academic reference found to Big Data, according to research by Marco Pospiech, a Ph. D. candidate at the Technical University of Freiberg in Germany.

By then, I had heard from Douglas Laney, an veteran data analyst at Gartner. His said the father of the term Big Data might well be John Mashey, who was the chief scientist at Silicon Graphics in the 1990s.

I replied to Mr. Diebold that I thought from what I had seen he probably had plenty of competition. And I passed along the e-mail correspondence I had received. Mr. Diebold said thanks much, and added that he had a University of Pennsylvania research librarian looking into it as well.

The term Big Data is so generic that the hunt for its origin was not just an effort to find an early reference to those two words being used together. Instead, the goal was the early use of the term that suggests its present connotation — that is, not just a lot of data, but different types of data handled in new ways.

The credit, it seemed to me, should go to someone who was aware of the computing context. That is why, in my view, a very intriguing reference, discovered by the Yale researcher Mr. Shapiro, does not qualify.

In 1989, Erik Larson, later the author of bestsellers including “The Devil in the White City” and “In The Garden of Beasts,” wrote a piece for Harper’s Magazine, which was reprinted in The Washington Post. The article begins with the author wondering how all that junk mail arrives in his mailbox and moves on to the direct-marketing industry. The article includes these two sentences: “The keepers of big data say they do it for the consumer’s benefit. But data have a way of being used for purposes other than originally intended.”

Prescient indeed. But not, I don’t think, a use of the term that suggests an inkling of the technology we call Big Data today.

Since I first looked at how he used the term, I liked Mr. Mashey as the originator of Big Data. In the 1990s, Silicon Graphics was the giant of computer graphics, used for special-effects in Hollywood and for video surveillance by spy agencies. It was a hot company in the Valley that dealt with new kinds of data, and lots of it.

There are no academic papers to support the attribution to Mr. Mashey. Instead, he gave hundreds of talks to small groups in the middle and late 1990s to explain the concept and, of course, pitch Silicon Graphics products. The case for Mr. Mashey is on the Web sites of technical and professional organizations, like Usenix. There, some of his presentation slides from those talks are posted, including “Big Data and the Next Wave of Infrastress” in 1998.

For me, looking for the origins of Big Data has been a matter of personal curiosity, something to get back to someday and write up on a weekend.

When I called Mr. Mashey recently, he said that Big Data is such a simple term, it’s not much a claim to fame. His role, if any, he said, was to popularize the term within a portion of the high-tech community in the 1990s. “I was using one label for a range of issues, and I wanted the simplest, shortest phrase to convey that the boundaries of computing keep advancing,” said Mr. Mashey, a consultant to tech companies and a trustee of the Computer History Museum in Mountain View, Calif.

At the University of Pennsylvania, Mr. Diebold kept looking into the subject as well. His follow-up inquiries, he said, proved to be “a journey of increasing humility.” He has written to two papers since the first one.

His most recent paper concludes: “The term Big Data, which spans computer science and statistics/econometrics, probably originated in the lunch-table conversations at Silicon Graphics in the mid-1990s, in which John Mashey figured prominently.”

Tracing the origins of Big Data points to the evolution in the field of etymology, according to Mr. Shapiro. The Yale researcher began his word-hunting nearly 35 years ago, as a student at the Harvard Law School, poring through the library stacks. He was an early user of databases of legal documents, news articles and other documents, in computerized archives.

The Web, Mr. Shapiro said, opens up new linguistic terrain. “What you’re seeing is a marriage of structured databases and novel, less structured materials,” he said. “It can be a powerful tool to see far more.”

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Media Decoder Blog: In Wake of Restructuring, NBC News President Quits

8:30 p.m. | Updated

The longest-serving president of any of the three network news divisions, Steve Capus of NBC News, stepped down from his position on Friday, six months after Comcast restructured its news units in a way that diminished his authority.

Pat Fili-Krushel, chairwoman of the NBCUniversal News Group, said in a brief telephone interview on Friday that she would “cast a wide net” while searching for a successor to Mr. Capus. In the interim, the leaders of the news division will report directly to her.

Ms. Fili-Krushel became Mr. Capus’s boss last July when Steve Burke, the chief executive of NBCUniversal, consolidated all of NBC’s news units — NBC News, the cable news channels MSNBC and CNBC, and its stake in the Weather Channel — under a new umbrella, the NBCUniversal News Group. Mr. Burke asked Ms. Fili-Krushel, one of his most trusted lieutenants, to run it, while keeping Mr. Capus and the heads of the other units in place.

Ms. Fili-Krushel worked early in her career at HBO and Lifetime. A veteran of the Walt Disney Company, where she helped program ABC, and  Time Warner, where she was an administrator, she is by her own admission not a journalist.  But now she is, by default, the highest-ranking woman in the American television news industry — not just at the moment, but in the history of the medium. The heads of the news divisions at ABC and CBS are men, as are the heads of the Fox News Channel, CNN, and Bloomberg.

Ms. Fili-Krushel has kept a low public profile, but has been a forceful presence behind the scenes, recently moving from her office on the 51st floor of 30 Rockefeller Center, near Mr. Burke’s, to a new one on the third floor, where NBC News is based. On Friday, she said she had spent her first six months “learning, listening and getting to know the players here.” She called the News Group an “unbelievably strong organization.”

Though Mr. Capus’s exit saddened many at NBC News on Friday, it came as little surprise. He had previously reported directly to Mr. Burke, but after the restructuring he reported to Ms. Fili-Krushel, and he made no secret of his unhappiness with the change. His contract had a clause that allowed him to leave in the event that he no longer reported to Mr. Burke, according to two people with direct knowledge of the arrangement at NBC, and he decided to exercise that right after months of contemplation. The people insisted on anonymity because they were not authorized by the network to speak publicly.

Mr. Capus told Ms. Fili-Krushel of his intent to leave last Friday. It is likely that he would have left sooner, but a series of major news stories kept him busy late last year — including Hurricane Sandy, the presidential election and the school shooting in Newtown, Conn. Mr. Capus also oversaw the network’s response to the kidnapping of Richard Engel and an NBC News crew in Syria last month.

“It has been a privilege to have spent two decades here, but it is now time to head in a new direction,” he wrote in an e-mail to staff members on Friday afternoon.

Mr. Capus guided NBC through a revolutionary time in news-gathering and distribution. He maintained the news division’s profitability, managed tensions between NBC News and its increasingly liberal cable channel MSNBC, and fostered new business ventures like an in-house production company and an annual education summit. Last year, he unwound an old deal with Microsoft to give the news division complete control over its Web site, now named NBCNews.com, for the first time.

Ms. Fili-Krushel wrote in a separate e-mail to staff members that “NBC News is America’s leading source of television news and Steve has been a big part of that success.”

NBC News is the producer of the most popular evening newscast in the country. But its single biggest source of profits, the morning show “Today,” fell to second place last year, behind ABC’s “Good Morning America,” for the first time since the 1990s. The decline caused widespread anxiety inside the news division and speculation that Mr. Capus would be relieved of his duties.

Inside NBC, both Mr. Capus and the executive producer of “Today,” Jim Bell, received much of the blame for the botched removal of Ann Curry from “Today” last June, which worsened the show’s already tenuous position in the ratings. Ms. Fili-Krushel was put in charge just a few weeks later.

Mr. Bell was replaced at “Today” last fall and is now the executive producer for NBC Olympics. Savannah Guthrie is now the co-host of “Today,” and Ms. Curry is a national and international correspondent for the network, but is rarely seen. Mr. Capus’s exit was seen by some at the network as the last shoe that had to drop.

In his e-mail to staff members, Mr. Capus called it an “extremely difficult decision to walk away,” noting that he started at NBC as a producer 20 years ago this month. He did not make any mention of what he would do next. “Journalism is, indeed, a noble calling, and I have much I hope to accomplish in the next phase of my career,” he wrote.

“Today” continues to lose to ABC’s “Good Morning America” among total viewers, but lately it has won a few weeks in the 25- to 54-year-old demographic that advertisers covet.

“NBC Nightly News” has more successfully fended off ABC’s “World News,” despite an aggressive push by ABC. Mr. Capus said, “NBC News has grown in all key metrics — from ratings and reputation to profitability.”

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